VCU Molecular Biology and Genetics

Jeff Dupree

Jeff Dupree
Associate Professor of Anatomy and Neurobiology

Degree: Ph.D., Virginia Commonwealth University
Research interest: Identification of factors that mediate neuron-oligodendrocyte interactions in the adult nervous system; determining the consequences that result when these cell-cell communications are disrupted. Our recent work indicates that a specific oligodendrocyte lipid, sulfatide, is required for the maintenance of neuron-oligodendrocyte interactions and for proper neuronal function and viability. Since recent clinical findings show that a significant sulfatide reduction is an early and consistent finding in several forms of dementia including Alzheimer's disease, our work may provide important insight into the pathogenesis of human neurodegenerative disease.
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